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Solid-phase Synthesis of [4.4] Spirocyclic Oximes
Published on: February 6, 2019
Synthesis of C-N or C-C Spiroindolines via Rearrangement Coupling Reaction
Xiaoling Liu1, Panpan Qiao1, Hui Chen1
1Key Laboratory of Molecule Synthesis and Function Discovery, College of Chemistry, Fuzhou University, Fuzhou, Fujian 350116, China.
Abstract:
Herein, we report a general approach to effectively construct C-N or C-C spiroindolines using tetrahydro-β-carbolines as starting materials via a rearrangement coupling reaction. This method is characterized by its operational simplicity and mild conditions. Notably, a wide range of anilines and indoles are suitable for this intermolecular coupling, yielding the corresponding C-N or C-C spiroindolines in good to excellent yields.
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