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Updated: Jun 9, 2025

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Opportunities and Solutions: Unintentional Weight Loss.

Rebecca Guterman1, Andy S Chu, Rebecca Hirsch

  • 1At Perlmutter Cancer Center, NYU Langone Health, New York, New York, USA, Rebecca Guterman, MS, RD, CSO, CDN, is Clinical Nutrition Manager; Andy S. Chu, MS, RD, CDN, CNSC, FAND; Rebecca Hirsch, MS, RD, CDN; Judy Singer, MPH, RD, CDN; Sarah Johnston, RD, CDN; and Katy Fung, MS, RD, CSO, CDN, are Registered Dietitians.

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Summary

Unintentional weight loss (UWL) is common and multifactorial. Early screening, nutrition assessment, and individualized management plans are key for effective clinical care and addressing UWL across patient lifecycles.

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Area of Science:

  • Clinical Nutrition
  • Geriatrics
  • Internal Medicine

Background:

  • Unintentional weight loss (UWL) is a prevalent clinical issue with multifactorial causes.
  • Identifying and managing UWL is crucial for patient outcomes and quality of life.

Purpose of the Study:

  • To provide a concise overview of current information on identifying and managing UWL in clinical settings.
  • To guide clinicians in the screening, assessment, and management of patients experiencing UWL.

Main Methods:

  • Narrative review of existing literature on unintentional weight loss.
  • Synthesis of information on screening tools, diagnostic approaches, and therapeutic interventions.
  • Discussion of UWL management within multidisciplinary care teams and at end-of-life.

Main Results:

  • Screening tools are recommended for identifying individuals at risk of UWL.
  • Management involves comprehensive nutrition assessments, diagnosing malnutrition, and tailored interventions.
  • Nutrition counseling, dietary plans, supplementation, and appetite stimulants are important management strategies.

Conclusions:

  • Effective management of UWL requires a proactive, multidisciplinary approach.
  • Individualized care plans addressing nutrition and patient goals are essential.
  • Addressing UWL is integral to comprehensive patient care, including end-of-life planning.