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Updated: Jun 9, 2025

Efficient Synthesis of All-Carbon Quaternary Centers via the Conjugate Addition of Functionalized Monoorganozinc Bromides
Published on: May 26, 2019
1,3-Difunctionalization of Donor-Acceptor Cyclopropanes Enabled by Copper Nitrate: A Direct Approach to
Ruoxin Huang1, Mingchun Gao1, Zhenkun Yang1
1Department of Chemistry, Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong), Shanghai Engineering Research Center of Organ Repair, Innovative Drug Research Center, School of Medicine, Shanghai University, Shanghai 200444, People's Republic of China.
Abstract:
1,3-Difunctionalization of donor-acceptor cyclopropanes with copper nitrate and N-halosuccinimide was developed to efficiently afford γ-halonitrates. The pivotal factor of this protocol lies in the dual role of copper nitrate as a Lewis acid and an ideal nitrooxy source. The given approach features easy handling, good functional group compatibility, and wide substrate scope. Furthermore, various transformations of the obtained γ-chloronitrates underscore the remarkable synthetic potential inherent in this method.
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