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Dry Film Photoresist-based Electrochemical Microfluidic Biosensor Platform: Device Fabrication, On-chip Assay Preparation, and System Operation

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Published on: September 19, 2017

Reusable gallium-based electrochemical sensor for efficient glucose detection.

Qian Wang¹, Caicai Jiao¹, Wuliang Chen¹

¹Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, 100191, China.

Biosensors & Bioelectronics

|October 31, 2024

Summary

This study introduces a reusable gallium-based electrochemical biosensor for continuous, noninvasive glucose monitoring in interstitial fluid. The novel sensor design offers high sensitivity and stability, extending the service life of wearable biochemical detection devices.

Keywords:

Gallium Glucose detection PEDOT Reusable electrochemical sensor

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Area of Science:

Biomedical Engineering
Electrochemistry
Biosensing Technology

Background:

Electrochemical sensors are vital for biochemical detection but often disposable, limiting their practical application.
Developing reusable sensors is crucial for long-term monitoring and reducing waste in wearable technology.

Purpose of the Study:

To develop a reusable gallium-based multilayer electrochemical biosensor for noninvasive glucose monitoring.
To enhance the sensitivity, stability, and selectivity of electrochemical glucose detection.
To enable continuous in vivo monitoring of interstitial fluid glucose levels.

Main Methods:

Fabrication of a multilayer sensor using gallium, poly(3,4-ethylenedioxythiophene), nano-platinum, and nano-Prussian blue.
Utilizing electrolysis-induced bubbles for self-renewal of the sensor's modified nanocomposites.
Integration with reverse iontophoresis for in vivo interstitial fluid sampling in rats.

Main Results:

The biosensor demonstrated high sensitivity (24.6 μA mM⁻¹ cm⁻²), a wide linear range (0.01–26 mM), and excellent stability and selectivity.
The sensor's reusability was confirmed through an electrochemical self-renewal process.
In vivo studies showed a good correlation between the sensor's readings and a blood glucometer.

Conclusions:

The reusable gallium-based biosensor offers a promising solution for long-term, noninvasive glucose monitoring.
This technology advances Ga-based bioelectronic devices by introducing biochemical analysis capabilities.
The electrochemically controllable reusability paves the way for more integrated and stable biosensing systems.