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Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

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Folate-engineered chitosan nanoparticles: next-generation anticancer nanocarriers.

Prashant Kesharwani¹, Kratika Halwai², Saurav Kumar Jha³

¹Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, 110062, India. prashantdops@gmail.com.

Molecular Cancer

|November 1, 2024

Summary

Chitosan nanoparticles offer a surfactant-free method for enhanced anticancer drug delivery, improving solubility and targeting specific cancers. Folate-engineered nanoparticles can overcome drug resistance and enable effective oral administration for improved cancer therapy.

Keywords:

Anticancer efficacy Chitosan Folate receptor Nanomedicine Nanoparticles Solubility

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Area of Science:

Biomaterials Science
Nanotechnology
Cancer Therapeutics

Background:

Chitosan nanoparticles (NPs) are effective drug delivery vehicles for anticancer agents.
They enhance solubility, permeability, and bioavailability of hydrophobic drugs via surfactant-free solubilization.
Chitosan NPs enable controlled drug release, increasing efficacy and reducing dosing frequency.

Purpose of the Study:

To review the fabrication, characterization, and applications of chitosan-based NPs for cancer treatment.
To explore the potential of folate-engineered chitosan NPs in targeting cancers overexpressing folate receptors.
To discuss the role of these NPs in overcoming drug resistance and improving oral drug delivery.

Main Methods:

Fabrication and characterization techniques for chitosan NPs.
Incorporation of anticancer drugs and folate targeting moieties.
Evaluation of drug release kinetics and targeting efficiency in FR-overexpressing cancer models.

Main Results:

Chitosan NPs demonstrate surfactant-free solubilization of hydrophobic anticancer drugs.
Folate-anchored chitosan NPs effectively target cancer cells with overexpressed folate receptors (FRs).
These NPs show potential in overcoming conventional treatment resistance and enhancing oral drug absorption.

Conclusions:

Folate-engineered chitosan NPs represent a promising strategy for targeted cancer therapy.
They offer improved drug delivery, overcome resistance mechanisms, and facilitate oral administration.
Further research into tailoring chitosan NPs can lead to more effective and patient-friendly cancer treatments.