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Differences in Static and Dynamic Resting-State Functional Connectivity between Migraineurs with and without
Noboru Imai1, Asami Moriya1, Eiji Kitamura2
1Department of Neurology, Japanese Red Cross Shizuoka Hospital, Shizuoka 420-0853, Japan.
Neurosci
|November 1, 2024
Summary
Migraineurs with photophobia exhibit reduced resting-state functional connectivity between the cerebellum and temporal lobe. This finding highlights a specific neural pathway alteration in migraine with light sensitivity.
Area of Science:
- Neuroscience
- Neurology
- Medical Imaging
Background:
- Previous studies indicated differences in resting-state functional connectivity (rsFC) between migraineurs with and without sensory sensitivities.
- Some photophobic migraineurs also experience phonophobia or osmophobia, complicating the understanding of photophobia-specific changes.
Purpose of the Study:
- To investigate the specific resting-state functional connectivity alterations in migraineurs with photophobia, excluding those with phonophobia or osmophobia.
- To compare static and dynamic rsFC between migraineurs with photophobia and those without, controlling for other sensory symptoms.
Main Methods:
- Functional magnetic resonance imaging (fMRI) was used to assess rsFC in 15 migraineurs with photophobia (no phonophobia/osmophobia) and 15 controls during the interictal phase.
- Region-of-interest analyses were performed on 91 cortical, 15 subcortical, and 26 cerebellar areas to compare static and dynamic rsFC.
Main Results:
- Static rsFC analysis identified ten significant connectivity pairs in the photophobia group.
- Dynamic rsFC analysis revealed six significant connectivity pairs in the photophobia group.
- Migraineurs with photophobia showed significantly lower connectivity between the cerebellar hemisphere and temporal regions in both static and dynamic analyses compared to controls.
Conclusions:
- Lower resting-state functional connectivity between the cerebellar hemisphere and temporal region is a specific characteristic of migraineurs with photophobia.
- These findings suggest a distinct neural signature for photophobia in migraine patients.
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