Related Experiment Video
Updated: Jun 8, 2025

Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway
Published on: August 23, 2024
Unexplained Rhabdomyolysis and Hepatic Renal Dysfunction: A Case of Bongkrekic Acid Poisoning
RongMing Hu1, TieGang Fu2, SenLin Xia1
1Emergency Medicine, Huzhou Central Hospital, Huzhou, CHN.
Abstract:
Bongkrekic acid (BA) is a lipotoxin that can cause fatal food poisoning. Severe BA poisoning can rapidly progress from liver and kidney damage to multiple organ failure and is rarely manifested as persistent hypoglycemia and rhabdomyolysis. It has a high mortality rate and poor prognosis. However, clinical data on patients with foodborne BA poisoning are limited. The aim of this study is to summarize the characteristics of patients with BA poisoning, provide reference for early diagnosis and treatment, and improve the survival rate and prognosis of patients with BA poisoning.
Related Concept Videos
Drug Elimination by Renal Route: Tubular Reabsorption
Enhanced Elimination of Poison
Antidotes serve a crucial role in counteracting the effects of poison by inhibiting enzymes responsible for producing harmful drug metabolites. In some cases, these toxic metabolites can be neutralized by endogenous cosubstrates, which are maintained at specific concentrations to prevent interaction with cellular macromolecules and subsequent cell death.
Renal excretion is the...
Renal Failure: Dose Adjustments
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
Dialysis
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
Anticholinesterase Agents: Poisoning and Treatment
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is...
Overview of Protein Metabolism
Amino acids play various roles in the body once they are absorbed into cells. They are restructured...

