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Updated: Jun 8, 2025

Inactivation of Pathogens via Visible-Light Photolysis of Riboflavin-5′-Phosphate
Published on: April 6, 2022
A giant macrocycle overcomes the post-treatment phototoxicity of photofrin through host-guest complexation
Shujie Lin1, Xiang Yu2, Ziliang Zhang1
1State Key Laboratory of National Security Specially Needed Medicines, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, P. R. China. jychen_msc@yeah.net.
Abstract:
Here we reported a supramolecular sequestration strategy to overcome the post-treatment phototoxicity of photofrin via direct host-guest complexation. Efficient recognition potency of a giant pentaphen[3]arene derivative could favor suppressing sunlight-induced skin damage through weakening the ability of complexed photofrin to generate singlet oxygen.
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