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Exploring Causal Correlations Between Inflammatory Cytokines and Kawasaki Disease: A Mendelian Randomization
1Department of Pediatrics, The First Affiliated Hospital of Yangtze University, Jingzhou, China.
Background:
The role of inflammatory cytokines in Kawasaki disease (KD) pathogenesis is known, but causal relationships are unclear. This study investigates these connections using Mendelian randomization (MR).
Methods:
Genetic variations associated with KD were obtained from a GWAS including 119 cases and 6071 controls of European ancestry. Genetic data on inflammatory cytokines were sourced from a GWAS of 8,293 healthy participants.
Results:
The study identified significant associations between higher levels of macrophage colony stimulating factor (M-CSF), monocyte chemotactic protein-1 (MCP-1), and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and increased risk of KD. The odds ratios (OR) were 1.04 (95% CI: 1.01-1.08, p = 0.010) for M-CSF, 1.03 (95% CI: 1.01-1.05, p = 0.026) for MCP-1, and 1.02 (95% CI: 1.01-1.04, p = 0.027) for TRAIL.
Conclusion:
This study suggests that M-CSF, MCP-1, and TRAIL are potentially involved in the etiology of KD.
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