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Deciphering the roles of cellular and extracellular non-coding RNAs in chemotherapy-induced cardiotoxicity

Pan Feng1, Fan Yang2, Dongmei Zang3

  • 1Baoji Hospital of Traditional Chinese Medicine, Baoji, 721000, China.

Molecular and Cellular Biochemistry
|November 1, 2024
PubMed

Insights

Non-coding RNAs (ncRNAs) play a role in chemotherapy-induced cardiotoxicity. This review explores ncRNAs as potential biomarkers and therapies for early detection and mitigation of heart damage.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cardiology

Background:

  • Chemotherapy-induced cardiotoxicity is a significant clinical challenge.
  • Non-coding RNAs (ncRNAs) are increasingly recognized for their roles in both cancer and cardiovascular diseases.
  • The specific involvement of ncRNAs in cardiotoxicity requires further elucidation.

Purpose of the Study:

  • To review current knowledge on ncRNAs in Cardio-Oncology.
  • To explore the potential of ncRNAs as biomarkers for diagnosing and predicting cardiotoxicity.
  • To investigate ncRNA-based therapeutic strategies for mitigating chemotherapy-induced heart damage.

Main Methods:

  • Literature review of studies on ncRNAs in cancer and cardiovascular diseases.
  • Analysis of the role of various ncRNA types (miRNAs, lncRNAs, circRNAs) in cardiotoxicity.
  • Exploration of extracellular RNAs (exRNAs) as potential mediators.

Main Results:

  • ncRNAs are crucial regulators of gene expression with implications in cellular states.
  • Over 97% of the genome is transcribed into diverse ncRNAs.
  • ncRNAs can function both intracellularly and extracellularly, influencing recipient cells.

Conclusions:

  • ncRNAs hold significant promise as biomarkers for early detection of cardiotoxicity.
  • ncRNA-based therapies could offer novel strategies for preventing or treating chemotherapy-induced heart damage.
  • Further research into ncRNAs in Cardio-Oncology can advance clinical applications and patient outcomes.
Keywords:
CardiotoxicityCellularChemotherapyExtracellularNon-coding RNAs

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