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Global Elimination of Hepatitis C Virus
Rachael L Fleurence1, Harvey J Alter2, Francis S Collins3
1Office of the Director, National Institutes of Health, Bethesda, Maryland, USA;
Annual Review of Medicine
|November 1, 2024
Summary
Hepatitis C virus (HCV) elimination is achievable by 2030, but requires accelerated global efforts. Addressing barriers like diagnostics, cost, and stigma is crucial for reaching this public health goal.
Area of Science:
- Public Health
- Infectious Diseases
- Virology
Background:
- Hepatitis C virus (HCV) infection affects millions globally, causing significant mortality despite being curable.
- Transmission primarily occurs through parenteral exposure to infectious blood or body fluids.
- Barriers to HCV elimination include limited diagnostics, treatment costs, stigma, and challenges in reaching marginalized populations.
Purpose of the Study:
- To assess the global progress and challenges in achieving Hepatitis C virus elimination by 2030.
- To highlight the importance of public health strategies and national plans for HCV elimination.
Main Methods:
- Review of global HCV infection statistics and mortality rates.
- Analysis of barriers hindering HCV elimination efforts.
- Examination of national and international strategies for HCV elimination.
Main Results:
- Despite being curable, HCV infected 58 million people worldwide in 2019, leading to 290,000 deaths.
- Significant progress toward elimination has been made in some countries, with national plans emerging.
- Global progress is uneven, necessitating accelerated efforts to meet the World Health Organization's 2030 elimination goals.
Conclusions:
- Global elimination of Hepatitis C virus is within reach.
- Sustained public health prioritization and accelerated action are essential to overcome existing barriers and achieve the 2030 elimination targets.
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