Recent advances on polydeoxyribonucleotide extraction and its novel application in cosmeceuticals

Polydeoxyribonucleotide (PDRN) is a registered DNA-derived proprietary drug containing a mixture of DNA fragments of molecular weights of 50 and 1500 kDa extracted mainly from salmon with a highly pure active substance (>95 %). It has many valuable medicinal effects and multi-functions related to cosmeceuticals. In-vivo tests and even clinical trials have confirmed this substance as non-toxic. Its promising bioactivities and safety profile have prompted increasing research and discovery of this active ingredient. However, most previous review papers have only focused on the bioactivities of PDRN in medicine and mainly evaluated the efficiency of salmon-derived sources. Only one review has elucidated the capacity of PDRN as promising anti-aging without mentioning other effects in cosmeceuticals. Thus, an overview of novel sources for the extraction of PDRN and their functions in the cosmeceuticals field is lacking, and is the main topic of discussion in this review. Besides general information about PDRN, this review evaluated the advantages and disadvantages of different novel sources and procedures for PDRN extraction. The bioactivities of PDRN regarding cosmeceuticals are also elucidated comprehensively. This review aims to supply worthy scientific information for further studies on PDRN extraction and its bioactivity in cosmeceuticals.