Hyaluronic acid application strategies for plant bioactive component delivery: A review

Despite the notable therapeutic effects of bioactive components derived from naturally occurring medicinal plants, various factors such as low solubility, poor bioavailability, possible toxicity, and inadequate tumor targeting capabilities generally hinder their full potential. Hyaluronic Acid (HA), a naturally occurring polysaccharide, has recently attracted significant research interest from scientists owing to its ability to precisely target tumors, anionic polysaccharide properties, and easily modifiable unique structure. In addition to offering a solid backing for delivering plant bioactive constituents, these remarkable attributes also have considerable implications for drug delivery systems in the future. This review delves into HA's application in delivering plant bioactive components, starting with a summary of HA's functional characteristics and detailing its strategies for single and dual-component delivery. The review also provides a forward-looking analysis of the challenges encountered in developing HA-based drug delivery systems.