A comprehensive review on guar gum and its modified biopolymers: Their potential applications in tissue engineering

Guar gum (GG), as a non-exudate gum, is extracted from the seed's embryos of Cyamopsis tetragonoloba (a member of Leguminosae family). Recently, this biopolymer has received extensive attention due to its low cost, notable properties, non-toxic biodegradation, ease of availability, and biocompatibility. However, disadvantages such as uncontrolled hydration rate and susceptibility to microbial attack have led many researchers to further modification of guar gum. Further modifications of guar gum heteropolysaccharide have been performed to improve properties and explore and expand its potential. The favorable biostability, improved solubility, and swelling, increased pH sensitivity, and good antibacterial and antioxidant properties indicate the significant advantages of the modified gum structures with different functional groups. In this review, the rapid growth in research on GG derivatives-based materials has been discovered. Besides, the production methods of GG and its derivatives have been discussed in tissue engineering and regenerative medical. Consequently, this review highlights the advances in the production of guar-based products to outline a promising future for this biopolymer by changing its properties and expanding its applications in potential targets.