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Algae-inspired chitosan-pullulan-based multifunctional hydrogel for enhanced wound healing.

Taishan Liu1, Huan Lei1, Linlin Qu2

  • 1Engineering Research Center of Western Resource Innovation Medicine Green Manufacturing, Ministry of Education, School of Chemical Engineering, Northwest University, Xi'an, 710069, China; Shaanxi Key Laboratory of Degradable Biomedical Materials and Shaanxi R&D Center of Biomaterials and Fermentation Engineering, School of Chemical Engineering, Northwest University, Xi'an, 710069, China; Biotech. & Biomed. Research Institute, Northwest University, Xi'an, 710069, China.

Carbohydrate Polymers
|November 1, 2024
PubMed
Summary

A novel QPMP hydrogel effectively treats chronic diabetic wounds by providing oxygen, fighting bacteria, and reducing inflammation. This conductive material integrates diagnosis and treatment, significantly improving wound healing compared to traditional dressings.

Keywords:
ChlorellaOxygen productionSchiff-based reaction；chronic wound healing

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Wound Healing

Background:

  • Diabetic chronic wounds present significant challenges due to hyperglycemia, hypoxia, and infection.
  • Effective wound repair strategies are crucial for improving patient outcomes.

Purpose of the Study:

  • To develop and evaluate a novel conductive, oxygen-producing hydrogel (QPMP) for chronic wound healing in diabetic patients.
  • To assess the hydrogel's antioxidant, antimicrobial, and anti-inflammatory properties.

Main Methods:

  • Preparation of QPMP hydrogel using quaternized chitosan (QCS), oxidized pullulan polysaccharide (OP), dopamine-coated polypyrrole (PPY@PDA), and Chlorella vulgaris.
  • Evaluation of hydrogel's antimicrobial and antioxidant activities, including near-infrared (NIR) irradiation effects.
  • Assessment of oxygen production under light conditions and its impact on wound healing.
  • In vivo testing on a chronic wound model to compare with a commercial dressing (HeraDerm).

Main Results:

  • The QPMP hydrogel demonstrated significant antioxidant and antimicrobial properties.
  • Chlorella vulgaris facilitated continuous oxygen production, alleviating hypoxia.
  • PPY@PDA incorporation provided NIR-assisted bactericidal and antioxidant effects.
  • The hydrogel exhibited conductivity for sensing wound exudate and temperature.
  • In vivo studies showed reduced inflammation, enhanced collagen deposition and angiogenesis, and faster wound closure compared to HeraDerm.

Conclusions:

  • The developed QPMP hydrogel is a promising conductive, oxygen-producing material for chronic diabetic wound management.
  • Its multifaceted properties, including integrated diagnosis and treatment capabilities, offer significant benefits over conventional dressings.
  • This innovative hydrogel accelerates wound healing by addressing key pathological factors in diabetic wounds.