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Updated: Jun 8, 2025

Isolation of Leukocytes from Human Breast Milk for Use in an Antibody-dependent Cellular Phagocytosis Assay of HIV Targets
Published on: September 6, 2019
Research on Maternal Vaccination for HIV Prevention
Krithika P Karthigeyan1, Christian Binuya1, Kenneth Vuong1
1Department of Pediatrics, Weill Cornell Medicine, 413 East 69th Street, BB-869E, New York City, NY 10021, USA.
Abstract:
Despite increased uptake of antiretroviral therapy (ART) among pregnant people living with human immunodeficiency virus (HIV), vertical transmission remains the most important route of pediatric HIV acquisition. The numbers of HIV acquisitions in infancy have remained alarmingly stagnant in recent years. It is evident that additional strategies that can synergize with ART will be required to end the pediatric HIV epidemic. In this review, we discuss the potential for immune-based interventions that can be administered in conjunction with current ART-based strategies to the birthing parent for prevention of vertical transmission of HIV-1, and the potential challenges associated with each approach.
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