Differences in IgG afucosylation between groups with and without carotid atherosclerosis.
Cuihong Tian1,2,3,4,5,6, Xingang Li3, Hongxia Zhang7
1Department of Cardiology, First Affiliated Hospital of Shantou University Medical College, Shantou, 515041, Guangdong, China.
BMC Cardiovascular Disorders
|November 2, 2024
Summary
Reduced IgG fucosylation is linked to carotid atherosclerosis (CAS) in Han Chinese. This finding suggests afucosylation plays a role in CAS development, potentially through enhanced antibody-dependent cell-mediated cytotoxicity.
Area of Science:
- Immunology
- Biochemistry
- Cardiovascular Medicine
Background:
- Previous research linked IgG N-glycosylation to subclinical atherosclerosis in a British population.
- Generalizability to other ethnicities and accounting for traditional risk factors required further investigation.
Purpose of the Study:
- To explore IgG N-glycosylation profiles in Han Chinese with atherosclerosis.
- To investigate the role of IgG N-glycosylation in atherosclerosis, controlling for traditional risk factors.
Main Methods:
- A case-control study involving 69 carotid atherosclerosis (CAS) cases and 69 matched controls.
- Serum IgG N-glycosylation was profiled using Ultra-Performance Liquid Chromatography.
- Propensity score matching controlled for traditional atherosclerosis risk factors.
Main Results:
- Significantly lower relative abundance of IgG fucosylation in CAS cases compared to controls (P=0.022).
- No statistically significant differences in traditional atherosclerosis risk factors between cases and controls.
Conclusions:
- Reduced IgG fucosylation is associated with CAS in the Han Chinese population.
- Afucosylation may play a pivotal role in CAS pathogenesis.
- Potential mechanism involves enhanced IgG inflammatory capability via antibody-dependent cell-mediated cytotoxicity.
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