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Association between atherogenic index of plasma and incident aortic disease: a population-based prospective analysis

Cuihong Tian1,2,3,4,5, Xiao Wang6, Liang Tao6

  • 1Department of Cardiology, First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong 515041, China.

Open Heart
|October 10, 2025
PubMed

Insights

The atherogenic index of plasma (AIP) is linked to a higher risk of aortic disease, particularly aortic aneurysm. This finding suggests AIP is a valuable tool for assessing aortic disease risk.

Area of Science:

  • Cardiovascular research
  • Lipidology
  • Aortic disease research

Background:

  • The atherogenic index of plasma (AIP) is a lipid-based biomarker.
  • AIP reflects both atherogenic and protective lipoprotein effects on cardiometabolic health.
  • The association between AIP and aortic disease risk is not well-established.

Purpose of the Study:

  • To investigate the association between AIP and the risk of incident aortic disease.
  • To determine if AIP can serve as an effective risk assessment tool for aortic diseases.

Main Methods:

  • A large-scale, population-based, prospective cohort study using UK Biobank data.
  • 17,530 participants aged 40-70 years were analyzed.
  • Aortic disease (aortic dissection and aortic aneurysm) was the composite outcome, with a median follow-up of 15.1 years.

Main Results:

  • A linear trend was observed between AIP and incident aortic disease risk (p=0.134).
  • Elevated AIP tertiles showed a stepwise increase in aortic disease risk (Tertile 3 aHR=2.04).
  • The highest AIP tertile was significantly associated with increased aortic aneurysm risk (aHR=2.47).

Conclusions:

  • AIP is significantly associated with an increased risk of incident aortic disease.
  • AIP demonstrates potential as an effective risk assessment method for aortic disease, especially aortic aneurysm.
Abstract

Keywords:
Aneurysm, DissectingAortic AneurysmEpidemiologyPUBLIC HEALTHRisk Factors

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