Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

What is Genetic Engineering?00:49

What is Genetic Engineering?

73.7K
Overview
73.7K
CRISPR01:59

CRISPR

49.6K
Genome editing technologies allow scientists to modify an organism’s DNA via the addition, removal, or rearrangement of genetic material at specific genomic locations. These types of techniques could potentially be used to cure genetic disorders such as hemophilia and sickle cell anemia. One popular and widely used DNA-editing research tool that could lead to safe and effective cures for genetic disorders is the CRISPR-Cas9 system. CRISPR-Cas9 stands for Clustered Regularly Interspaced...
49.6K
Homologous Recombination02:31

Homologous Recombination

50.2K
The basic reaction of homologous recombination (HR) involves two chromatids that contain DNA sequences sharing a significant stretch of identity. One of these sequences uses a strand from another as a template to synthesize DNA in an enzyme-catalyzed reaction. The final product is a novel amalgamation of the two substrates. To ensure an accurate recombination of sequences, HR is restricted to the S and G2 phases of the cell cycle. At these stages, the DNA has been replicated already and the...
50.2K
Animal Mitochondrial Genetics02:59

Animal Mitochondrial Genetics

7.5K
Among all the organelles in an animal cell, only mitochondria have their own independent genomes. Animal mitochondrial DNA is a double-stranded, closed-circular molecule with around 20,000 base pairs. Mitochondrial DNA is unique in that one of its two strands, the heavy, or H, -strand is guanine rich, whereas the complementary strand is cytosine rich and called the light, or L, -strand. Compared to nuclear DNA, mitochondrial DNA has a very low percentage of non-coding regions and is marked by...
7.5K
Synthetic Biology02:55

Synthetic Biology

4.7K
Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
Golden rice
Golden rice is a genetically modified...
4.7K
CRISPR and crRNAs02:53

CRISPR and crRNAs

16.8K
Bacteria and archaea are susceptible to viral infections just like eukaryotes; therefore, they have developed a unique adaptive immune system to protect themselves. Clustered regularly interspaced short palindromic repeats and CRISPR-associated proteins (CRISPR-Cas) are present in more than 45% of known bacteria and 90% of known archaea.
The CRISPR-Cas system stores a copy of foreign DNA in the host genome and uses it to identify the foreign DNA upon reinfection. CRISPR-Cas has three different...
16.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

"Everyone Hears Everyone's Business": Health Care Provider Perspectives on Privacy and Confidentiality in U.S. Prisons and Jails.

Journal of correctional health care : the official journal of the National Commission on Correctional Health Care·2026
Same author

Perceptions of Polygenic Scores for Medical and Social Traits Among Biobank Participants and the Public.

Biopreservation and biobanking·2026
Same author

How parents and community care professionals use a genetic diagnosis to inform care: expanding the concept of utility.

Journal of community genetics·2026
Same author

Egalitarian Justice and the Prevalence Principle in Human Genome Editing.

The Journal of medicine and philosophy·2026
Same author

Distinguishing social and medical traits: perspectives of scientists using polygenic scores.

Journal of community genetics·2026
Same author

"I'd probably trip over it because it's bumpy": A qualitative exploration of the lived experiences of ambulatory children with cerebral palsy walking in challenging environments.

PloS one·2025

Related Experiment Video

Updated: Jun 8, 2025

Enhanced Genome Editing with Cas9 Ribonucleoprotein in Diverse Cells and Organisms
09:51

Enhanced Genome Editing with Cas9 Ribonucleoprotein in Diverse Cells and Organisms

Published on: May 25, 2018

33.8K

Preventive Human Genome Editing and Enhancement: Candidate Criteria for Governance.

Eric Juengst, Michael A Flatt, John M Conley

    The Hastings Center Report
    |November 2, 2024
    PubMed
    Summary

    Preventive strengthening research (PSR) aims to boost disease resistance beyond normal human limits. This research faces ethical debates, as it may be perceived as human enhancement, requiring careful policy development.

    Keywords:
    bioethicsenhancementhuman genome editingprevalencepreventive strengtheningpublic dialoguereversibility

    More Related Videos

    Establishment of Genome-edited Human Pluripotent Stem Cell Lines: From Targeting to Isolation
    09:51

    Establishment of Genome-edited Human Pluripotent Stem Cell Lines: From Targeting to Isolation

    Published on: February 2, 2016

    13.6K
    Genome Editing and Directed Differentiation of hPSCs for Interrogating Lineage Determinants in Human Pancreatic Development
    09:37

    Genome Editing and Directed Differentiation of hPSCs for Interrogating Lineage Determinants in Human Pancreatic Development

    Published on: March 5, 2017

    13.1K

    Related Experiment Videos

    Last Updated: Jun 8, 2025

    Enhanced Genome Editing with Cas9 Ribonucleoprotein in Diverse Cells and Organisms
    09:51

    Enhanced Genome Editing with Cas9 Ribonucleoprotein in Diverse Cells and Organisms

    Published on: May 25, 2018

    33.8K
    Establishment of Genome-edited Human Pluripotent Stem Cell Lines: From Targeting to Isolation
    09:51

    Establishment of Genome-edited Human Pluripotent Stem Cell Lines: From Targeting to Isolation

    Published on: February 2, 2016

    13.6K
    Genome Editing and Directed Differentiation of hPSCs for Interrogating Lineage Determinants in Human Pancreatic Development
    09:37

    Genome Editing and Directed Differentiation of hPSCs for Interrogating Lineage Determinants in Human Pancreatic Development

    Published on: March 5, 2017

    13.1K

    Area of Science:

    • Bioethics
    • Human Genome Editing
    • Preventive Medicine

    Background:

    • Somatic cell editing for disease treatment is accepted, but human genome editing for enhancement is ethically contested.
    • The perception of enhancement can create significant barriers for scientific, public, and regulatory approval of genome editing projects.
    • Preventive genome editing research, particularly aimed at enhancing disease resistance, is a key area of ethical concern.

    Purpose of the Study:

    • To explore the ethical implications of "preventive strengthening research" (PSR) by examining how strengthening disease resistance beyond the typical human range may be interpreted as human enhancement.
    • To identify and critique candidate criteria for developing normative guidance for PSR.
    • To anticipate the emergence of PSR and the need for a robust ethical and regulatory framework.

    Main Methods:

    • Conceptual analysis of "preventive strengthening research" (PSR).
    • Identification and critique of three "candidate criteria" for guiding PSR.
    • Exploration of the interface between preventive goals and enhancement implications in genome editing.

    Main Results:

    • PSR, aimed at enhancing disease resistance, blurs the line between prevention and enhancement.
    • Existing ethical frameworks may struggle to differentiate between therapeutic and enhancement applications of genome editing.
    • Three candidate criteria for guiding PSR were identified and critiqued, highlighting challenges for policy development.

    Conclusions:

    • Developing guidance for PSR requires navigating the complex relationship between disease prevention and human enhancement.
    • A normative approach is crucial for addressing the ethical challenges posed by PSR.
    • Further research and policy development are needed to establish clear guidelines for the responsible pursuit of PSR.