An open-source framework for the generation of OpenSim models with personalised knee joint geometries for the...

Musculoskeletal modelling pipelines typically use generic models scaled to individual's anthropometry. The ability to represent variations in bone or joint geometry and alignment is highly limited. This may have a large effect, particularly when modelling contact between articular surfaces such as for the knee where articular contact mechanics are used to determine joint kinematics and the resulting cartilage contact pressures and locations. Here we describe a developed open-source framework for the personalisation of such models and compare dynamic simulation outputs. The framework involves three main steps: (1) positions personalised geometries from magnetic resonance imaging and replaces generic bone and contact geometries. (2) Repositions muscle and ligament attachments and via points and optimisation of wrapping surfaces to ensure physiological lengthening behaviour. Finally, (3) muscle and ligament properties are calibrated to ensure physiological behaviour. Following model creation, dynamic simulations from a single participant and gait trial were compared. Small changes in knee adduction/abduction and rotation angles were observed between models. Joint moment differences however were present in not only the knee but also hip and ankle joints. These differences resulted in changes in both the magnitude and location of knee joint contact pressure. The framework developed is automated and requires only minimal user interaction and is built using open-source software packages which can be freely downloaded and installed. The adoption of such personalised modelling approaches facilitates patient specific modelling and may provide more detailed information regarding disease progression, patient stratification and facilitate personalised rehabilitation and treatment planning.