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Study protocol for a sequential multiple assignment randomized trial to decrease alcohol use before and after

Xintong Ju1, Jake Solka1, Estevan Pena1

  • 1Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA.

Contemporary Clinical Trials
|November 3, 2024
PubMed
Summary
This summary is machine-generated.

This study investigates adaptive interventions, including Virtual Health Coaching, to reduce high-risk alcohol use in surgical patients. The goal is to improve postoperative recovery and long-term health outcomes.

Keywords:
Adaptive interventionAlcohol useElective surgeryPostoperative recoverySequential multiple assignment randomized trial (SMART)

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Area of Science:

  • Medical research
  • Surgical patient care
  • Behavioral health interventions

Background:

  • High-risk alcohol consumption perioperatively presents significant risks to surgical recovery.
  • Elective surgical patients often lack access to alcohol-focused education and treatment.
  • This study protocol addresses the need for effective interventions to mitigate perioperative alcohol risks.

Purpose of the Study:

  • To evaluate the effectiveness of brief, non-pharmacological, therapeutic approaches to reduce alcohol use before and after surgery.
  • To compare preoperative Virtual Health Coaching (VHC) with Enhanced Usual Care (EUC) in reducing high-risk alcohol use.
  • To identify optimal postoperative strategies for sustained alcohol use reduction over 12 months.

Main Methods:

  • The Alcohol Screening and Preoperative Intervention Research (ASPIRE-2) study employs a Sequential, Multiple Assignment, Randomized Trial (SMART) design.
  • 440 elective, non-cancer surgery patients (ages 21-75) reporting high-risk alcohol use are included.
  • Adaptive interventions involve preoperative VHC or EUC, followed by tailored postoperative strategies based on patient response.

Main Results:

  • The study aims to determine the effectiveness of adaptive interventions in reducing perioperative alcohol consumption.
  • It seeks to identify the most successful postoperative strategies for long-term alcohol use reduction.
  • Secondary aims include identifying moderators of intervention effectiveness and evaluating surgical outcomes.

Conclusions:

  • The ASPIRE-2 study introduces an innovative adaptive intervention approach for perioperative alcohol reduction.
  • This research addresses the critical need to manage alcohol use risks associated with elective surgery.
  • The findings are expected to inform clinical practice and improve surgical patient outcomes.