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Papaverine-induced chronic liver disease.
Gastroenterology
|April 1, 1986
Summary
This case study reveals that papaverine, a medication for cerebral arterial disease, can induce chronic active hepatitis and cirrhosis. Discontinuation of papaverine led to symptom improvement, suggesting a causal link.
Area of Science:
- Hepatology
- Clinical Pharmacology
- Toxicology
Background:
- A patient with cerebral arterial disease was treated with papaverine for six years.
- The patient presented with jaundice, indicating potential liver dysfunction.
Observation:
- The patient exhibited laboratory evidence of chronic active hepatitis and cirrhosis.
- Jaundice and liver abnormalities fluctuated with papaverine administration and withdrawal.
- Presence of antinuclear antibody and smooth muscle antibody suggested an autoimmune component.
Findings:
- Papaverine therapy was associated with the development of chronic active hepatitis and cirrhosis.
- Withdrawal of papaverine resulted in the resolution of clinical manifestations and normalization of laboratory results.
Implications:
- Papaverine should be considered a potential causative agent for drug-induced chronic active hepatitis and cirrhosis.
- This case highlights the importance of considering medication side effects in the differential diagnosis of liver disease.
- Further investigation into the hepatotoxicity of papaverine is warranted.
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