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Spermine Synthase : A Potential Prognostic Marker for Lower-Grade Gliomas
Chen Liu1,2,3, Hongqi Li2, Xiaolong Hu4
1Medical School of Chinese PLA, Beijing, China.
Journal of Korean Neurosurgical Society
|November 4, 2024
Summary
Spermine synthase (SMS) is upregulated in lower-grade gliomas (LGGs), promoting tumor growth and influencing immune cells. High SMS expression indicates a poorer prognosis for LGG patients.
Area of Science:
- Neuro-oncology
- Molecular Biology
- Immunology
Background:
- Lower-grade gliomas (LGGs) are primary brain tumors with variable prognosis.
- Understanding molecular markers associated with LGG development and progression is crucial for improved patient outcomes.
Purpose of the Study:
- To investigate the role of spermine synthase (SMS) expression in lower-grade gliomas (LGGs).
- To assess the relationship between SMS expression, tumor occurrence, and patient prognosis.
Main Methods:
- Analyzed SMS expression in 523 LGG tissues and 1152 normal brain tissues.
- Utilized Mann-Whitney U test, Spearman correlation, Cox regression, and bioinformatics analyses.
- Conducted in vitro experiments to evaluate SMS effects on cell proliferation, apoptosis, and migration.
Main Results:
- SMS expression was significantly upregulated in LGGs compared to normal tissues.
- High SMS expression correlated with adverse clinical features and poorer survival outcomes.
- SMS upregulation was linked to altered immune cell infiltration, including decreased dendritic cells and CD8+ T cells.
Conclusions:
- Elevated SMS expression in LGGs may drive tumor initiation and progression via cellular proliferation and immune modulation.
- SMS serves as a potential prognostic biomarker for predicting clinical outcomes in LGG patients.
