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Accuracy of Diagnosing Optic Neuritis Using DANTE T1-SPACE Imaging
Ayaka Shimada1,2, Kenji Suda1, Eri Nakano1
1Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Eye and Brain
|November 4, 2024
Summary
Delay alternating with nutation for tailored excitation (DANTE) T1-SPACE imaging demonstrates superior sensitivity for diagnosing optic neuritis compared to other MRI sequences. This advanced MRI technique correlates with clinical findings, aiding in diagnosis and treatment assessment.
Area of Science:
- Ophthalmology
- Radiology
- Neuroscience
Background:
- Optic neuritis diagnosis can be challenging, requiring sensitive imaging techniques.
- Magnetic Resonance Imaging (MRI) plays a crucial role in evaluating optic nerve inflammation.
Purpose of the Study:
- To evaluate the diagnostic utility of DANTE T1-SPACE MRI for optic neuritis.
- To compare DANTE T1-SPACE with other MRI sequences (VIBE, STIR).
- To analyze the correlation between DANTE T1-SPACE findings and clinical parameters.
Main Methods:
- Retrospective analysis of 36 eyes from 30 patients with optic neuritis or NA-AION.
- MRI scans included post-contrast DANTE T1-SPACE, VIBE, and STIR sequences.
- Independent review of MRI scans by three ophthalmologists.
Main Results:
- DANTE T1-SPACE showed significantly higher sensitivity (100%) for optic neuritis detection than STIR (67%, p=0.009).
- VIBE imaging did not consistently confirm enhancement in optic neuritis lesions.
- DANTE T1-SPACE lesion length correlated with retinal nerve fiber layer thickness, eye pain, and symptom-to-MRI interval.
Conclusions:
- Contrast-enhanced DANTE T1-SPACE is a more sensitive MRI sequence for diagnosing optic neuritis.
- DANTE T1-SPACE aids in understanding the relationship between imaging findings and clinical presentation.
