Related Experiment Video
Updated: Jun 8, 2025
10:10
A 3D Human Lung Tissue Model for Functional Studies on Mycobacterium tuberculosis Infection
Published on: October 5, 2015
18.9K
Vitamin D Receptor Gene Polymorphisms Differentiated Between Tuberculosis Disease and Infection: Causal Association
Jaina Razbek1, Yanggui Chen2, Jiandong Yang2
1Department of Epidemiology and Health Statistics, College of Public Health, Xinjiang Medical University, Urumqi, 830011, People's Republic of China.
Infection and Drug Resistance
|November 4, 2024
Summary
Vitamin D receptor (VDR) gene polymorphisms, particularly BsmI and TaqI loci, are linked to tuberculosis (TB) risk. Manual labor combined with specific VDR gene types significantly increases TB susceptibility.
Area of Science:
- Immunogenetics
- Tuberculosis Research
- Genetic Epidemiology
Background:
- Latent tuberculosis infection (LTBI) is a crucial stage in tuberculosis (TB) control.
- Few studies have explored the immunogenetic role of vitamin D receptor (VDR) gene polymorphisms in distinguishing between active TB and LTBI.
Purpose of the Study:
- To investigate the association between VDR gene polymorphisms and tuberculosis disease status.
- To analyze causal relationships between VDR polymorphisms and TB using a Bayesian network approach.
Main Methods:
- Propensity score matching (PSM) was used to create comparable groups of LTBI and TB patients.
- Bayesian network modeling was employed to analyze VDR polymorphisms and their influence on TB risk.
- Logistic regression identified specific VDR loci associated with increased TB risk.
Main Results:
- VDR gene polymorphisms at BsmI, TaqI, and ApaI loci were associated with a higher risk of TB (P<0.05).
- Occupation (manual labor) and the VDR BsmI locus were identified as direct risk factors for TB.
- The VDR TaqI locus indirectly influenced TB risk through the BsmI locus.
Conclusions:
- Individuals with manual labor and the VDR BsmI C/T genotype have an 84.15% probability of TB risk.
- Bayesian network analysis highlights VDR BsmI locus and physical labor as key determinants of TB risk.
- Findings provide evidence for targeted TB control strategies focusing on genetic predisposition and occupational factors.
More Related Videos
Related Concept Videos
01:31Pulmonary Tuberculosis III
305
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
The first classification is based on the development of the disease, and it includes the following categories:
305
01:26Pulmonary Tuberculosis IV
134
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
134
01:29Pulmonary Tuberculosis I
220
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
220
01:11Genome-wide Association Studies-GWAS
12.5K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
12.5K
01:28Pulmonary Tuberculosis II
212
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
212
01:21Causality in Epidemiology
322
Causality or causation is a fundamental concept in epidemiology, vital for understanding the relationships between various factors and health outcomes. Despite its importance, there's no single, universally accepted definition of causality within the discipline. Drawing from a systematic review, causality in epidemiology encompasses several definitions, including production, necessary and sufficient, sufficient-component, counterfactual, and probabilistic models. Each has its strengths and...
322