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Updated: Jun 8, 2025

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
Silver-mediated radical cascade trifluoromethylthiolation/cyclization of benzimidazole derivatives with AgSCF3
Pan Liu1, Yang Geng2, Dapeng Zou1
1College of Chemistry, Zhengzhou University, Zhengzhou 450001, People's Republic of China. zdp@zzu.edu.cn.
Abstract:
A silver-mediated cascade trifluoromethylthiolation/cyclization of unactivated alkenes has been investigated. This strategy employs AgSCF3 as the trifluoromethylthiolating reagent to obtain a variety of useful trifluoromethylthiolated tricyclic imidazol derivatives in reasonable yields. Preliminary mechanistic studies indicate that the present reaction takes place via a radical process. This method is distinguished by its atom economy, wide functional group compatibility, operational simplicity and product diversity.
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