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Updated: Jan 11, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
Visible-light-induced radical trifluoromethylation/cyclization of alkynes: synthesis of CF3-containing
Xiaoyu Chen1, Yang Geng2, Pan Liu3
1Flavors and Fragrance Engineering and Technology Research Center of Henan Province, College of Tobacco Science, Henan Agricultural University, Zhengzhou, 450046, P. R. China. xiaoyuchen@henau.edu.cn.
Abstract:
A simple and metal-free photoinduced radical trifluoromethylation/cyclization reaction of alkynes with readily preparable and air-stable trifluoromethyl thianthrenium triflate (TT-CF3+OTf-) as the trifluoromethyl source has been developed. This transformation can be carried out without using metal catalysts and strong oxidants, providing an avenue to construct a series of potential pharmaceutically valuable trifluoromethylated dioxodibenzothiazepines under mild conditions. This protocol offers a green strategy for the synthesis of useful CF3-containing seven-membered N-heterocycles.
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