Efficient bionic nanozyme based on AuPt NPs@ZIF-90 used for cyclic catalysis multimodal tumor therapy

Area of Science:

• Biomedical Engineering
• Nanotechnology
• Oncology

Background:

• Nanozymes offer promise for tumor treatment but face limitations in catalytic efficiency and tumor hypoxia.
• Developing effective nanozyme-based multimodal therapies is crucial for improving cancer treatment outcomes.

Purpose of the Study:

• To develop a novel nanozyme, ZAAP, with enhanced catalytic activity for synergistic tumor therapy.
• To investigate the multimodal therapeutic effects of ZAAP, including chemical dynamic, photothermal, and starvation therapies.

Main Methods:

• Synthesized ZAAP by embedding gold and platinum nanoparticles into ZIF-90, incorporating midazole-2-carboxaldehyde (ICA).
• Evaluated ZAAP's multi-enzymatic cascade (peroxidase, catalase, glucose oxidase) and its ability to generate ROS and oxygen.
• Assessed the synergistic therapeutic efficacy of ZAAP in a tumor model, including tumor inhibition rates.

Main Results:

• ZAAP demonstrated a 23-fold enhancement in peroxidase activity within a bionic catalytic microenvironment.
• The nanozyme facilitated a catalytic cycle for continuous ROS and oxygen generation, alleviating tumor hypoxia.
• ZAAP achieved a 96.4% tumor inhibition rate within two weeks via synergistic chemical dynamic/photothermal/starvation therapy.

Conclusions:

• ZAAP represents a promising nanozyme platform for multimodal tumor treatment.
• The synergistic approach effectively combats tumor hypoxia and enhances therapeutic outcomes.
• ZAAP shows significant potential for advancing nanozyme-based cancer therapies.