Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Total occlusion does not disrupt photoreceptor alignment.

R A Applegate, A J Adams, A Bradley

    Investigative Ophthalmology & Visual Science
    |March 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    A multi-estuary assessment of pharmaceutical exposure and risk of pharmacological effects in a recreational fishery.

    Environmental toxicology and chemistry·2025
    Same author

    Widespread pharmaceutical exposure at concentrations of concern for a subtropical coastal fishery: Bonefish (Albula vulpes).

    Marine pollution bulletin·2024
    Same author

    Differential tissue distribution of pharmaceuticals in a wild subtropical marine fish.

    Aquatic toxicology (Amsterdam, Netherlands)·2024
    Same author

    Genome Wide Conditional Mouse Knockout Resources.

    Drug discovery today. Disease models·2024
    Same author

    Identifying pathways of pharmaceutical exposure in a mesoconsumer marine fish.

    Journal of hazardous materials·2024
    Same author

    From eDNA to decisions using a multi-method approach to restoration planning in streams.

    Scientific reports·2024
    Same journal

    Impact of Subretinal Drusenoid Deposits on Ellipsoid Zone-Related Thickness Metrics.

    Investigative ophthalmology & visual science·2026
    Same journal

    Proteomic Profiling of Optic Nerves From SMOX-Deficient Mice Identifies Regulators of Neuroinflammation and Axonal Damage in Optic Neuritis.

    Investigative ophthalmology & visual science·2026
    Same journal

    Aflibercept and Faricimab Equipotently Restore Endothelial Barrier Function.

    Investigative ophthalmology & visual science·2026
    Same journal

    Spatial Decomposition of Longitudinal RNFL Maps Reveals Distinct Modes of Glaucomatous Progression With Structure-Function and Genetic Signatures.

    Investigative ophthalmology & visual science·2026
    Same journal

    The CXXC1-IGFBP6 Axis Maintains Corneal Epithelial Differentiation via H3K4me3-Dependent Transcriptional Activation.

    Investigative ophthalmology & visual science·2026
    Same journal

    Archetypal Visual Field Analysis of Patients With Chronic Leber Hereditary Optic Neuropathy in Relation to Visual Recovery.

    Investigative ophthalmology & visual science·2026
    See all related articles

    Total eye occlusion did not alter the photopic Stiles-Crawford function (SCF). This challenges previous findings suggesting a phototropic mechanism actively maintains photoreceptor alignment in human vision.

    Area of Science:

    • Ophthalmology
    • Visual Neuroscience
    • Photoreceptor Physiology

    Background:

    • The photopic Stiles-Crawford function (SCF) describes how the eye's sensitivity to light varies with pupil position.
    • Previous studies inferred a phototropic mechanism, which actively aligns photoreceptors, based on SCF changes during pupil manipulation.

    Purpose of the Study:

    • To investigate the effect of prolonged total eye occlusion on the photopic Stiles-Crawford function.
    • To replicate and potentially expand upon previous findings regarding photoreceptor alignment mechanisms.

    Main Methods:

    • Full SCFs were measured in three normal human eyes and one abnormal eye.
    • Measurements were taken before and after a period of at least six days of total eye occlusion.

    Related Experiment Videos

    Main Results:

    • Total eye occlusion resulted in minimal to no significant alterations in the SCF rho value.
    • This finding was consistent across both normal and the single abnormal eye examined.

    Conclusions:

    • The results contradict previous reports suggesting a significant role for a phototropic mechanism in maintaining photoreceptor alignment under occlusion.
    • Prolonged total eye occlusion does not appear to substantially affect the photopic Stiles-Crawford function in the tested eyes.