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AIntibody: an experimentally validated in silico antibody discovery design challenge

M Frank Erasmus1, Laura Spector2, Fortunato Ferrara2

  • 1Specifica LLC, an IQVIA business, Santa Fe, USA. mfrank.erasmus@iqvia.com.

Nature Biotechnology
|November 4, 2024
PubMed
Summary

No abstract available in PubMed .

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Antibody Structure01:10

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Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
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Hybridoma technology is used for the large-scale production of monoclonal antibodies. Monoclonal antibodies bind to only a single antigenic determinant or epitope. Such antibodies are used in research, diagnostics, and disease therapy. The hybridoma technology established in 1975 by Georges Köhler and Cesar Milstein was awarded the Nobel Prize in Medicine in 1984 for revolutionizing research and therapy.
Hybridoma Selection
Commonly used fusion techniques — electroporation, polyethylene glycol...

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