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A Neglected Point: Frailty in Older Adults with Differentiated Thyroid Cancer
Meric Coskun1, Esra Cataltepe2, Hacer Dogan Varan2
1Department of Endocrinology and Metabolism, Faculty of Medicine, Gazi University, Ankara, Turkey.
Endocrinology and Metabolism (Seoul, Korea)
|November 5, 2024
Summary
Older adults with differentiated thyroid cancer (DTC) and lower thyroid-stimulating hormone (TSH) levels face a higher risk of frailty, reduced muscle mass, and decreased strength. Careful TSH target setting is crucial for managing frailty in these patients.
Area of Science:
- Gerontology
- Endocrinology
- Oncology
Background:
- Differentiated thyroid cancer (DTC) is common in older adults.
- Frailty is a significant concern in aging populations.
- The relationship between thyroid-stimulating hormone (TSH) levels and frailty in DTC patients requires investigation.
Purpose of the Study:
- To assess frailty risk in older adults with DTC.
- To examine the impact of TSH levels on frailty in this population.
- To identify predictors of frailty in DTC patients.
Main Methods:
- A single-center, cross-sectional study of 70 DTC patients (age ≥60) with stable TSH.
- Frailty assessed using the Fried Frailty Phenotype (FFP).
- Muscle mass (ultrasound), strength (hand dynamometer), and physical activity (PASE) were measured.
Main Results:
- 58.6% of patients were prefrail or frail.
- Lower TSH levels were associated with prefrailty/frailty, low muscle mass, and low strength.
- TSH levels negatively correlated with FFP and positively with the STAR index.
- Low TSH (<1.325 μIU/mL) predicted increased frailty risk.
Conclusions:
- Lower TSH levels in older DTC patients are linked to higher frailty risk, reduced muscle mass, and diminished strength.
- Comprehensive evaluation, considering the risk-benefit ratio, is essential for setting TSH targets.
- Female sex, low handgrip strength, and low physical activity also predict frailty in this cohort.
Keywords:
Differentiated thyroid cancerFrailtyMuscle massMuscle strengthThyroid-stimulating hormone levelMore Related Videos
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