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Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
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Embryonic Stem Cells00:57

Embryonic Stem Cells

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Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
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Stem Cell Culture01:17

Stem Cell Culture

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Source And Potency Of Stem Cells01:27

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Stem cells are undifferentiated cells with extensive self-renewal properties that help them maintain their population during the fetal and adult stages of life. They can specialize in all cell types of the human body. However, their differential potential may vary and can be classified into five types. Stem cells can be (1) Totipotent, (2) Pluripotent, (3) Multipotent, (4) Oligopotent, and (5) Unipotent. Each stem cell has a specific origin; the fertilized egg or zygote is a totipotent cell and...
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Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

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Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
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Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
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Revolutionizing medicine: recent developments and future prospects in stem-cell therapy.

Bashdar M Hussen1,2, Mohammad Taheri3, Raya Kh Yashooa4

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Stem cell therapy offers transformative potential for treating diseases and injuries through regeneration and differentiation. This review explores its applications, challenges, and future directions in regenerative medicine.

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Area of Science:

  • Regenerative Medicine
  • Cell Biology
  • Biotechnology

Background:

  • Stem cell therapy represents a significant advancement in medicine.
  • Stem cells possess unique regenerative and differentiation capabilities.
  • Historical breakthroughs include embryonic stem cell (ESC) isolation and induced pluripotent stem cell (iPSC) discovery.

Purpose of the Study:

  • To review stem cell therapy processes, applications, and challenges.
  • To guide researchers, physicians, and stakeholders in the field.
  • To provide a nuanced understanding of stem cell-based regenerative medicine.

Main Methods:

  • Review of historical contributions and recent breakthroughs.
  • Examination of stem cell types (embryonic, adult, iPSC, perinatal).
  • Analysis of biotechnological advancements, clinical trials, and emerging technologies.

Main Results:

  • Stem cells offer therapeutic opportunities for cancer, neurodegenerative disorders, cardiovascular diseases, spinal cord injuries, diabetes, and tissue damage.
  • Challenges include immunological rejection, tumorigenesis, and precise stem cell manipulation.
  • Recent advancements and trials show progress in stem cell applications.

Conclusions:

  • Stem cell therapy holds significant promise for treating debilitating conditions.
  • Future directions involve precision medicine, immune modulation, gene editing, and bioengineering.
  • Individualized regenerative therapies are anticipated to alleviate numerous medical disorders.