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Predictive Accuracy of HeartMate 3 Risk Score After the Heart Transplant Allocation Change.

Justin D Vincent¹, Alyssa Ramsay², David S Lambert¹

¹From the Department of Medicine, Washington University School of Medicine, Saint Louis, Missouri.

ASAIO Journal (American Society for Artificial Internal Organs : 1992)

|November 5, 2024

Summary

The HeartMate 3 risk score (HM3RS) needs updating. It did not accurately predict patient outcomes after left ventricular assist device implantation in a real-world setting.

Keywords:

Heartmate 3 risk score MOMENTUM 3 UNOS heart transplant allocation system left ventricular assist device

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Area of Science:

Cardiology
Medical Devices
Outcomes Research

Background:

The HeartMate 3 risk score (HM3RS) was developed to predict mortality after left ventricular assist device (LVAD) implantation.
Validation in real-world populations, particularly after recent changes to heart transplant allocation, is lacking.

Purpose of the Study:

To validate the HM3RS in a contemporary, real-world population.
To assess the score's predictive accuracy for 1- and 2-year outcomes post-LVAD implantation.

Main Methods:

Multicenter retrospective analysis of patients receiving HeartMate 3 LVAD.
Evaluation of HM3RS performance in predicting 1- and 2-year mortality.

Main Results:

The HM3RS did not accurately predict 1- and 2-year outcomes in the contemporary real-world cohort.
The score's predictive utility appears diminished in the current clinical landscape.

Conclusions:

The HM3RS requires revision to accurately reflect outcomes in the current era.
A new risk prediction tool is needed for patients receiving HeartMate 3 LVADs.