Predictive Accuracy of HeartMate 3 Risk Score After the Heart Transplant Allocation Change

Area of Science:

• Cardiology
• Medical Devices
• Outcomes Research

Background:

• The HeartMate 3 risk score (HM3RS) was developed to predict mortality after left ventricular assist device (LVAD) implantation.
• Validation in real-world populations, particularly after recent changes to heart transplant allocation, is lacking.

Purpose of the Study:

• To validate the HM3RS in a contemporary, real-world population.
• To assess the score's predictive accuracy for 1- and 2-year outcomes post-LVAD implantation.

Main Methods:

• Multicenter retrospective analysis of patients receiving HeartMate 3 LVAD.
• Evaluation of HM3RS performance in predicting 1- and 2-year mortality.

Main Results:

• The HM3RS did not accurately predict 1- and 2-year outcomes in the contemporary real-world cohort.
• The score's predictive utility appears diminished in the current clinical landscape.

Conclusions:

• The HM3RS requires revision to accurately reflect outcomes in the current era.
• A new risk prediction tool is needed for patients receiving HeartMate 3 LVADs.