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Enhancing real world data interoperability in healthcare: A methodological approach to laboratory unit harmonization.

Aída Muñoz Monjas1, David Rubio Ruiz2, David Pérez Del Rey1

  • 1Biomedical Informatics Group, Universidad Politécnica de Madrid, Madrid, Spain.

International Journal of Medical Informatics
|November 5, 2024
PubMed
Summary

This study harmonized laboratory units to Unified Code for Units of Measure (UCUM) standards, achieving over 90% coverage. This improves clinical data interoperability for research.

Keywords:
Laboratory data standardizationReal-world dataSecondary useSemantic interoperabilityUCUMUnits of measurement

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Area of Science:

  • Biomedical Informatics
  • Health Data Standardization
  • Clinical Laboratory Science

Background:

  • Non-standardized units in clinical laboratory data hinder data interoperability and secondary use.
  • The Unified Code for Units of Measure (UCUM) provides a standard for units, but adoption is low, with ~60% of codes non-compliant.
  • Challenges in data comparability arise from inconsistent unit representations across healthcare organizations.

Purpose of the Study:

  • To design, implement, and test a methodology for harmonizing laboratory units to UCUM standards.
  • To address the critical issue of non-standardized units in clinical laboratory data.
  • To enhance data interoperability and usability for secondary data analysis within a large research network.

Main Methods:

  • Utilized dimensional analysis and a curated equivalence table for unit harmonization.
  • Focused on identifying and converting non-UCUM conforming units.
  • Applied the methodology across the TriNetX research network.

Main Results:

  • Achieved over 90% coverage of laboratory data units in UCUM standards within the TriNetX network.
  • Demonstrated a significant improvement in data interoperability compared to baseline measurements.
  • Facilitated more reliable and comparable data analysis across diverse healthcare organizations.

Conclusions:

  • The developed methodology successfully harmonized laboratory data units to UCUM standards, a key advancement in biomedical informatics.
  • This approach provides a practical solution to the challenge of non-standardized units, improving data usability for research.
  • Future work will address remaining standardization gaps and explore the impact on clinical outcomes and research capabilities.