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Combination therapy for psoriasis with methotrexate and etretinate
Journal of the American Academy of Dermatology
|January 1, 1986
Summary
Severe erythrodermic psoriasis and pustular episodes in two young males were effectively managed with combination therapy. Methotrexate and etretinate treatment for 2.5 years resulted in significant lesion clearing without notable side effects or hepatotoxicity.
Area of Science:
- Dermatology
- Pharmacology
Background:
- Erythrodermic psoriasis and pustular psoriasis are severe inflammatory skin conditions.
- Limited treatment options exist for severe, refractory cases.
Observation:
- Two young male patients with severe erythrodermic psoriasis and pustular episodes were treated.
- Combination therapy involved methotrexate and etretinate over 2.5 years.
Findings:
- Successful relative clearing of psoriatic lesions was achieved in both patients.
- No significant adverse effects, including hepatotoxicity, were observed during the treatment period.
Implications:
- Combination therapy with methotrexate and etretinate may be a safe and effective option for severe psoriasis.
- Further research into the safety and efficacy of this combination regimen is warranted.