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Vitamin D deficiency in pediatric sickle cell disease patients without crisis - A cry to investigate it on priority

Shahida Aziz Khan1,2, Torki Al Zughaibi1,2, Sarah A Khan2

  • 1King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia.

International Journal of Health Sciences
|November 6, 2024
PubMed

Insights

Vitamin D deficiency is common in children with sickle cell disease (SCD). Addressing low vitamin D levels early can reduce health complications in these vulnerable children.

Area of Science:

  • Pediatrics
  • Hematology
  • Endocrinology

Background:

  • Vitamin D deficiency (VDD) poses global health risks.
  • Children with sickle cell disease (SCD) are at heightened risk for comorbidities.
  • Early detection of VDD in SCD children is crucial to mitigate adverse effects.

Purpose of the Study:

  • To determine vitamin D levels in children with SCD during a stable state.
  • To investigate potential associations between vitamin D levels, inflammation, and infections in SCD children.

Main Methods:

  • Enrolled 5-16 year old children with SCD in a steady state.
  • Collected consent and ethical clearance.
  • Analyzed hemoglobin (Hb), serum calcium, vitamin D, and high-sensitivity C-reactive protein (hsCRP) levels.

Main Results:

  • Most SCD children exhibited vitamin D deficiency.
  • Significant correlations were observed between vitamin D levels and inflammatory markers (WBC, hsCRP) and Hb, particularly in older males and females.
  • Strong negative correlations were found between vitamin D and Hb/hsCRP in older males, and between vitamin D and WBC/hsCRP in older females.

Conclusions:

  • Vitamin D deficiency is prevalent in children with SCD.
  • Early intervention for VDD in SCD children is recommended to reduce comorbidity incidence and severity.
Abstract

Keywords:
Diagnostic markerearly interventionvitamin D

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