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Skin Barrier Parameters in Acne Vulgaris versus Normal Controls: A Cross-Sectional Analytic Study
Siriorn Sukanjanapong1, Monthanat Ploydaeng1, Penpun Wattanakrai1
1Division of Dermatology, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Clinical, Cosmetic and Investigational Dermatology
|November 6, 2024
Summary
Acne patients exhibit impaired skin barrier function, with higher transepidermal water loss (TEWL) and sebum production. Acne treatments may further compromise the skin barrier, suggesting a need for barrier-enhancing moisturizers.
Area of Science:
- Dermatology
- Skin Physiology
Background:
- Objective data on skin barrier parameters in acne patients are limited.
- Understanding these parameters can offer insights into acne vulgaris pathogenesis and treatment.
Purpose of the Study:
- To measure and compare skin barrier parameters in acne patients (with and without therapy) versus normal controls.
- To analyze factors influencing skin barrier parameters in acne.
Main Methods:
- A cross-sectional study involving 316 Thai volunteers (164 acne patients, 152 controls).
- Measurement of transepidermal water loss (TEWL), skin hydration, and sebum production.
- Multivariate regression analysis to adjust for confounding factors.
Main Results:
- Acne patients showed significantly higher TEWL, sebum production, and skin hydration compared to controls.
- Acne treatment was associated with the highest TEWL and altered skin hydration patterns.
- Differences remained significant after adjusting for confounding factors.
Conclusions:
- Acne patients exhibit compromised skin barrier function, characterized by elevated TEWL, sebum, and hydration.
- Acne treatments appear to exacerbate skin barrier impairment.
- Moisturizers with barrier-enhancing properties may benefit acne patients undergoing treatment.
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