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Updated: Jun 8, 2025

Assessment of Kidney Function in Mouse Models of Glomerular Disease
Published on: June 30, 2018
[Gliflozins: Proteinuria Control and Nephroprotection]
Simona Barbuto1, Veronica Catalano1, Marianna Pira1
1Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum - University of Bologna, Bologna, Italy.
Sodium-glucose cotransporter 2 inhibitors (SGLT2i) show significant promise in slowing the progression of chronic kidney disease (CKD) and diabetic kidney disease (DKD). These drugs offer vital nephroprotective and cardioprotective benefits for at-risk populations.
Area of Science:
- Nephrology
- Endocrinology
- Cardiology
Context:
- Chronic kidney disease (CKD) prevalence is rising globally, affecting over 843 million people.
- Diabetes mellitus and obesity are key drivers of CKD and diabetic kidney disease (DKD).
- DKD patients face high risks of cardiovascular morbidity and mortality.
Purpose:
- To review the role of sodium-glucose cotransporter 2 inhibitors (SGLT2i) in managing CKD and DKD.
- To highlight the nephroprotective and cardioprotective mechanisms of SGLT2i.
Summary:
- SGLT2 inhibitors demonstrate efficacy in reducing CKD and DKD progression.
- Key mechanisms include decreasing glomerular hyperfiltration and improving tubulo-glomerular feedback.
- Blood glucose reduction is a primary benefit of SGLT2 inhibitors.
Impact:
- SGLT2i offer a therapeutic strategy to mitigate CKD and DKD progression.
- These agents may reduce cardiovascular complications in diabetic patients.
- Improved kidney function and patient outcomes are anticipated.
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