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Perinatal Risk Factors in Single-suture Craniosynostosis: A Systematic Review and Meta-analysis
Martin Van Carlen1, Steven Lane2, Rosanna C Ching3
1Alder Hey Childrens Hospital, Liverpool.
The Journal of Craniofacial Surgery
|November 6, 2024
Summary
This review identified potential perinatal risk factors for single suture craniosynostosis, including maternal thyroid disease and smoking. Further research is needed to confirm these associations in pediatric patients.
Area of Science:
- Pediatric craniofacial surgery
- Perinatal epidemiology
Background:
- Single suture craniosynostosis affects pediatric patients.
- Understanding perinatal risk factors is crucial for prevention and early intervention.
Purpose of the Study:
- To systematically review and meta-analyze evidence on perinatal risk factors for single suture craniosynostosis.
- To inform clinical practice and identify research gaps.
Main Methods:
- Systematic review and meta-analysis of pediatric single-suture craniosynostosis patients.
- Literature search of OVID MEDLINE, Pubmed, and Embase (1946-2023).
- Pooled odds ratios and 95% confidence intervals (CIs) were calculated.
Main Results:
- 16 articles were included; 13 used for meta-analysis.
- Possible associations found with maternal thyroid disease, maternal age >29, paternal age >29, maternal smoking, gestational age >37 weeks, and maternal underweight (BMI<18.5).
Conclusions:
- Several perinatal factors may be associated with single suture craniosynostosis.
- Further prospective studies are warranted to establish definitive associations.
