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Updated: Jun 8, 2025
Tail Vein Transection Bleeding Model in Fully Anesthetized Hemophilia A Mice
Published on: September 30, 2021
[Rehabilitation and outcomes in acquired hemophilia A: a single-center clinical study]
Akira Matsumoto1, Yoshiyuki Ogawa1, Mikiya Kajita1
1Department of Hematology, Gunma University Graduate School of Medicine.
Abstract:
The main goals of acquired hemophilia A (AHA) therapy are to arrest bleeding using bypass agents and eradicate FVIII inhibitors using immunosuppressive therapy (IST). We treated a total of 25 patients with AHA in the past 10 years at Gunma University Hospital. Fifteen patients (60%) underwent rehabilitation during hospitalization. The median time from admission to the start of rehabilitation was 31 days (7-142 days). Median FVIII activity at the start of rehabilitation was 11.3% (2.9-79.8%), and median FVIII inhibitor was 2.1 BU/ml (<5.0-46.8 BU/ml). Only one patient (6.7%) had a bleeding event triggered by rehabilitation.
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