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Cardio-metabolic Disorders Affected by Genetic Polymorphisms Related to Premature Menopause
Mohammad Reza Mirinezhad1, Hamideh Safarian Bana2, Maliheh Aghsizadeh2
1Department of Medical Genetics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Genetic variations are linked to cardio-metabolic disorders in women experiencing premature menopause (PM). Specific gene polymorphisms increase the risk of metabolic syndrome and obesity in these individuals.
Area of Science:
- Endocrinology
- Genetics
- Cardiology
Background:
- Premature menopause (PM), or primary ovarian insufficiency, is diagnosed before age 40.
- PM is associated with an increased risk of cardiovascular disease.
Purpose of the Study:
- To investigate the association between single nucleotide polymorphisms (SNPs) and premature menopause.
- To evaluate the impact of these genetic variations on cardio-metabolic disorders within the MASHAD cohort.
Main Methods:
- A cross-sectional study comparing 117 women with PM to 183 healthy controls.
- Assessment of anthropometric indices and genotyping for eight selected polymorphisms in seven genes.
Main Results:
- Significant differences in physical activity levels were noted between groups.
- The rs4806660 CC genotype correlated with a 3.63-fold increased risk of metabolic syndrome.
- The rs2303369 TT genotype was associated with a 3.11-fold increased risk of obesity.
Conclusions:
- Genetic variations represent significant risk factors for cardio-metabolic disorders in women with premature menopause.
- Specific gene polymorphisms may predispose women with PM to metabolic syndrome and obesity.
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