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Impact of Chronic Moderate Psychological Stress on Skin Aging: Exploratory Clinical Study and Cellular Functioning
Muriel Pujos1, Cécile Chamayou-Robert1, Marine Parat1
1COTY Research and Development, Monaco, Monaco.
Journal of Cosmetic Dermatology
|November 7, 2024
Summary
Psychological stress (PS) significantly impacts skin aging, leading to decreased antioxidant potential, impaired barrier function, and increased fine lines. Cellular studies confirm stress hormones negatively affect DNA integrity and skin repair mechanisms.
Area of Science:
- Dermatology
- Cell Biology
- Stress Physiology
Background:
- Skin is constantly exposed to internal and external stressors, including psychological stress (PS).
- PS can exacerbate dermatological conditions like psoriasis, atopic dermatitis, and acne via stress hormone release.
Purpose of the Study:
- To investigate psychological stress-induced skin aging signs in chronic psoriasis patients.
- To examine the cellular effects of chronic psychological stress on skin health and DNA integrity.
Main Methods:
- In vitro stress tests using cortisol and epinephrine on skin cells and extracellular matrix synthesis.
- Assessment of skin barrier integrity, antioxidant potential, and microrelief alterations in human subjects.
- Evaluation of DNA integrity, ECM synthesis, wound healing, and barrier function at the cellular level.
Main Results:
- Moderately stressed individuals showed reduced antioxidant capacity, compromised skin barrier, and a 32.9% increase in fine lines and texture changes.
- Cellular studies revealed that elevated stress hormones negatively impacted DNA integrity, ECM production, wound healing, and skin barrier parameters.
Conclusions:
- Chronic psychological stress significantly disrupts skin homeostasis.
- Evidence suggests psychological stress is a key factor in accelerating skin aging and impacting skin health.
Keywords:
DNA damagecortisolepinephrineextracellular matrixpsychological stressskin agingskin barrierwound healingMore Related Videos
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