Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Pathophysiology of Peptic Ulcer Disease: Mucosal Defense Factors

Pathophysiology of Peptic Ulcer Disease: Mucosal Defense Factors

Peptic ulcer disease, commonly called PUD, represents a multifaceted condition characterized by disruptions in the lining of the gastrointestinal (GI) tract. Central to the protection of the gastrointestinal lining is the mucosal-bicarbonate barrier. This physiological defense mechanism is a formidable shield against the corrosive effects of gastric acid and pepsin secretion in the stomach. Its role is pivotal in maintaining the structural integrity of the stomach's inner lining.

Surface Membrane Barriers

Surface Membrane Barriers

The skin and mucous membranes serve as the primary line of defense against pathogens by providing both physical and chemical protection. These barriers are essential in preventing the entry and establishment of microbes, thereby maintaining the integrity of the host.
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...

Peptic Ulcer Disease II: Pathophysiology

Peptic Ulcer Disease II: Pathophysiology

Peptic Ulcer Disease (PUD) is characterized by the development of ulcers in the stomach or duodenal mucosa. Its pathophysiology is complex, involving a balance between damaging and protective elements.
Damaging agents such as Helicobacter pylori, gastric acid, pepsin, and nonsteroidal anti-inflammatory drugs (NSAIDs) can weaken the mucosal defense, allowing hydrogen ions to infiltrate back and harm epithelial cells.

Drugs for Peptic Ulcer Disease: Sucralfate as Mucosal Protective Agents

Drugs for Peptic Ulcer Disease: Sucralfate as Mucosal Protective Agents

In the intricate landscape of the gastric lumen, excessive acid secretion disrupts the natural defense mechanisms, weakening the mucus-bicarbonate barrier. This vulnerability allows pepsin to infiltrate epithelial cells, digesting mucosal proteins and triggering erosion, leading to ulcer formation.
In this scenario, mucosal protective agents like sucralfate play an essential role. Sucralfate, a complex of sulfated sucrose and aluminum hydroxide, demonstrates its usefulness in acidic conditions,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Odontome - A Single-institutional Cross-sectional Study of 31 Years from Mumbai and Case Report with Modified Gallego's Stain.

Journal of microscopy and ultrastructure·2026

Same authorSame journal

A Cauliflower-like Growth on the Anterior Mandibular Gingivae.

Journal of microscopy and ultrastructure·2026

Same author

Osteolipoma of the Oral Cavity: Case Report and Review of Literature.

Journal of microscopy and ultrastructure·2026

Same author

Red Blood Cells in Health and Disease.

Journal of microscopy and ultrastructure·2025

Same author

Pleomorphic Adenoma in an Immunocompromised Patient.

Journal of microscopy and ultrastructure·2025

Same author

Malignant Non-Odontogenic Tumors of the Oral Cavity - Single Institutional Retrospective Study of Three Decades.

Indian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine·2025

Search research articles

Related Experiment Video

Updated: Jun 8, 2025

Granulocyte-dependent Autoantibody-induced Skin Blistering

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

Oral Mucous Membrane Pemphigoid.

Cathy Babu¹, Sandhya Tamgadge², Rutuja Gajanan Vidhale¹

¹Departments of Oral and Maxillofacial Pathology and Microbiology, D. Y. Patil University School of Dentistry, Navi Mumbai, Maharashtra, India.

Journal of Microscopy and Ultrastructure

|November 7, 2024

Summary

This summary is machine-generated.

Mucous membrane pemphigoid, an autoimmune blistering disease, often presents with oral lesions. This case highlights a rare variant without skin or eye involvement, emphasizing diagnostic challenges.

Keywords:

Autoimmune disease basement membrane zone blisters

More Related Videos

Application of a Mouse Ligated Peyer’s Patch Intestinal Loop Assay to Evaluate Bacterial Uptake by M cells

Application of a Mouse Ligated Peyer’s Patch Intestinal Loop Assay to Evaluate Bacterial Uptake by M cells

Published on: December 17, 2011

Induction of Ocular Surface Inflammation and Collection of Involved Tissues

Induction of Ocular Surface Inflammation and Collection of Involved Tissues

Published on: August 4, 2022

Related Experiment Videos

Last Updated: Jun 8, 2025

Granulocyte-dependent Autoantibody-induced Skin Blistering

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

Application of a Mouse Ligated Peyer’s Patch Intestinal Loop Assay to Evaluate Bacterial Uptake by M cells

Application of a Mouse Ligated Peyer’s Patch Intestinal Loop Assay to Evaluate Bacterial Uptake by M cells

Published on: December 17, 2011

Induction of Ocular Surface Inflammation and Collection of Involved Tissues

Induction of Ocular Surface Inflammation and Collection of Involved Tissues

Published on: August 4, 2022

Area of Science:

Autoimmune diseases
Dermatology
Oral medicine

Background:

Pemphigoid encompasses rare autoimmune disorders targeting the basement membrane zone.
Autoantibodies against basement membrane antigens cause subepithelial blistering in skin and mucous membranes.
Oral lesions are present in over 90% of cases, often leading to early identification by oral health professionals.

Observation:

This report details a unique case of mucous membrane pemphigoid.
The patient presented with mucous membrane lesions but no ocular or cutaneous manifestations.
This presentation deviates from typical pemphigoid disease patterns.

Findings:

The case represents a rare variant of mucous membrane pemphigoid.
Absence of ocular and cutaneous involvement poses diagnostic challenges.
Timely diagnosis is crucial for effective management of autoimmune blistering diseases.

Implications:

Highlights the importance of considering pemphigoid variants even with atypical presentations.
Underscores the need for refined diagnostic criteria for autoimmune blistering diseases.
Emphasizes the critical role of oral health professionals in early pemphigoid detection.