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Related Concept Videos

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Social anxiety disorder, also known as social phobia, is characterized by an intense fear of social situations where one might face humiliation, rejection, embarrassment, or negative evaluation. This disorder leads individuals to avoid activities like casual conversations, public speaking, or seemingly simple tasks such as eating, signing documents, or swimming, in public settings. Its impact extends beyond discomfort, often significantly interfering with daily functioning and quality of life.
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Autism Spectrum Disorder01:19

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Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
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Updated: Jun 8, 2025

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Structural Brain Correlates of Anxiety During Development.

E Leighton Durham1, Antonia N Kaczkurkin2

  • 1Department of Psychological Sciences, Vanderbilt University, Nashville, TN, USA.

Current Topics in Behavioral Neurosciences
|November 7, 2024
PubMed
Summary

This review explores brain structure differences linked to youth anxiety disorders. Research shows varied brain region associations, highlighting the need for more neurodevelopmental studies in child anxiety.

Keywords:
AnxietyBrain structureCortical surface areaCortical thicknessObsessive-compulsive disorderPosttraumatic stress disorderVolumeYouth

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Area of Science:

  • Neuroscience
  • Developmental Psychology
  • Psychiatry

Background:

  • Anxiety disorders are common in youth, causing significant impairment.
  • Understanding neurodevelopmental links is crucial for identifying causes of youth anxiety.
  • Brain structure variations are increasingly associated with anxiety in young people.

Purpose of the Study:

  • To review and synthesize existing literature on neurostructural correlates of anxiety in youth.
  • To examine associations across different anxiety presentations and neurostructural measures.
  • To identify research gaps and future directions in the field.

Main Methods:

  • Systematic review and synthesis of published studies.
  • Focus on neurostructural modalities: brain volume, cortical thickness, and cortical surface area.
  • Inclusion of studies examining various anxiety disorders in youth.

Main Results:

  • Most research has focused on brain volume compared to cortical thickness or surface area.
  • Studies predominantly examined generalized anxiety, obsessive-compulsive disorder, and posttraumatic stress disorder.
  • Significant variability exists in implicated brain regions and the direction of associations.

Conclusions:

  • Current research on neurostructural correlates of youth anxiety is variable and has limitations.
  • Further investigation is needed into cortical thickness and surface area in relation to anxiety.
  • Future research should aim to clarify specific neurodevelopmental pathways involved in youth anxiety disorders.