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    This study introduces an iterative partial diffusion model (IPDM) for low-dose computed tomography (LDCT) imaging, improving generalization and reducing computational time for better image reconstruction.

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    Area of Science:

    • Medical Imaging
    • Artificial Intelligence
    • Computational Science

    Background:

    • Traditional deep learning reconstruction (DLR) methods struggle with diverse data distributions in low-dose computed tomography (LDCT), limiting their practical application.
    • Existing diffusion models for LDCT face challenges including high computational cost, training difficulties with high-resolution images, and performance degradation in denoising tasks.

    Purpose of the Study:

    • To develop a novel domain progressive LDCT imaging framework that overcomes the limitations of current DLR and diffusion model approaches.
    • To enhance the generalizability and efficiency of LDCT image reconstruction.

    Main Methods:

    • Proposes an iterative partial diffusion model (IPDM) framework that utilizes a fraction of the diffusion model for denoising, reducing time consumption and convergence issues.
    • Introduces a condition-guided sampling method to mitigate sampling bias from predictive data gradients and Langevin dynamics.
    • Implements an adaptive weight strategy based on pixel-wise noise estimation to dynamically adjust guided intensity during reconstruction.

    Main Results:

    • The proposed IPDM framework demonstrates superior performance over traditional iterative reconstruction, unsupervised, and supervised DLR methods in both visual and quantitative evaluations.
    • Achieves performance comparable to state-of-the-art supervised DLR techniques.
    • Exhibits enhanced generalization ability in practical imaging scenarios due to training on normal-dose CT data.

    Conclusions:

    • The novel IPDM framework offers a more efficient and generalizable solution for LDCT image reconstruction compared to existing methods.
    • The method effectively addresses the domain generalization problem in LDCT imaging, paving the way for improved clinical applications.
    • The developed framework balances strong generative capabilities with reduced computational demands, making it suitable for practical use.