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Related Experiment Video

Updated: Jun 8, 2025

Preparation of Chitosan-based Injectable Hydrogels and Its Application in 3D Cell Culture
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Customizable hydrospongel based on chitosan microfibers.

Zhenxiu Liu1, Yong Mei Chen1, Wenjun Shu2

  • 1College of Bioresources Chemical and Materials Engineering, National Demonstration Center for Experimental Light Chemistry Engineering Education, Shaanxi University of Science &Technology, Xi'an, Shaanxi 710021, China.

Journal of Colloid and Interface Science
|November 7, 2024
PubMed
Summary
This summary is machine-generated.

Researchers developed customizable chitosan microfibers (CMFs)-based hydrospongels that mimic soft tissue properties. These porous biomaterials offer excellent self-recovery and biocompatibility for implant scaffolds.

Keywords:
CustomizableHydrospongelPorous biomaterialRapid self-recoveryShearing thinning

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Tissue Engineering

Background:

  • Customizable and viscoelastic porous biomaterials are crucial for repairing large-volume tissue defects.
  • Existing scaffolds often lack the mechanical properties and self-recovery capabilities needed for soft tissue regeneration.

Purpose of the Study:

  • To develop novel chitosan microfibers (CMFs)-based hydrospongels with tunable mechanical properties and excellent self-recovery.
  • To evaluate the hemocompatibility, cytocompatibility, biodegradability, and potential as implant scaffolds for biomedical applications.

Main Methods:

  • Chitosan microfibers (CMFs) were synthesized via high-speed shearing and crystallized.
  • CMFs were crosslinked using covalent (glycerol triglycidyl ether - GTE) and hydrogen bonds to form hydrospongels.
  • Mechanical properties, self-recovery, customizability (2D/3D architectures), in vitro biocompatibility (hemolysis, cell assays), and in vivo biodegradability were assessed.

Main Results:

  • The resulting hydrospongels exhibited mechanical properties comparable to soft tissues and rapid self-recovery (1s) after large compression.
  • The CMF suspension displayed shear-thinning behavior, enabling the fabrication of various customizable 2D and 3D architectures.
  • In vitro and in vivo studies confirmed excellent hemocompatibility, cytocompatibility, non-toxicity, biodegradability, and lack of inflammatory response.

Conclusions:

  • CMFs-based hydrospongels offer a promising, green, and mass-producible platform for creating customizable implant scaffolds.
  • The unique combination of elasticity, sponge-like water absorption, and rapid self-recovery makes them suitable for biomedical applications.
  • These findings pave the way for advanced tissue engineering solutions using advanced biomaterials.