Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Recombinant DNA

Recombinant DNA

Transgenic Organisms

Transgenic Organisms

Types of Genetic Transfer Between Organisms

Types of Genetic Transfer Between Organisms

Genetic transfer occurs when genetic information is passed from one organism to another. It occurs via two mechanisms: vertical gene transfer and horizontal gene transfer. Vertical gene transfer occurs when genetic information is transferred from one generation to the next, which happens much more frequently than horizontal gene transfer. Both sexual and asexual reproduction are forms of vertical gene transfer, where one or more organisms pass some or all of their genome onto their progeny.

Recombinant DNA

Recombinant DNA

Transgenic Organisms

Transgenic Organisms

Types of Genetic Transfer Between Organisms

Types of Genetic Transfer Between Organisms

Genetic transfer occurs when genetic information is passed from one organism to another. It occurs via two mechanisms: vertical gene transfer and horizontal gene transfer. Vertical gene transfer occurs when genetic information is transferred from one generation to the next, which happens much more frequently than horizontal gene transfer. Both sexual and asexual reproduction are forms of vertical gene transfer, where one or more organisms pass some or all of their genome onto their progeny.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A Pan-Cancer Transcriptomic Signature for Conserved Molecular Programs Underlying Premalignant-Malignant Progression Across Common Carcinomas.

Dentistry journal·2026

Same author

Microwave-assisted immunostaining for rapid labeling of matrix-embedded multicellular structures.

APL bioengineering·2025

Same author

Perivascular cells function as key mediators of mechanical and structural changes in vascular capillaries.

Science advances·2025

Same author

A Linkable, Polycarbonate Gut Microbiome-Distal Tumor Chip Platform for Interrogating Cancer Promoting Mechanisms.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2024

Same author

Engineering models of head and neck and oral cancers on-a-chip.

Biomicrofluidics·2024

Same author

Enhancement of dielectrophoresis-based particle collection from high conducting fluids due to partial electrode insulation.

Electrophoresis·2023

Search research articles

Related Experiment Video

Updated: Jun 28, 2026

Bioprinting Cellularized Constructs Using a Tissue-specific Hydrogel Bioink

Bioprinting Cellularized Constructs Using a Tissue-specific Hydrogel Bioink

Published on: April 21, 2016

Remote-Controlled Gene Delivery in Coaxial 3D-Bioprinted Constructs using Ultrasound-Responsive Bioinks.

Mary K Lowrey^1,2, Holly Day^1,2, Kevin J Schilling^1,2

¹Biomedical Engineering Department, Oregon Health and Science University, Portland, OR 97201 USA.

Cellular and Molecular Bioengineering

|November 8, 2024

Summary

This study introduces a novel 3D bioprinting method using ultrasound-responsive gene delivery bioinks. This technique enables precise, remote control over gene transfection in engineered tissues, advancing disease modeling and regenerative medicine.

Keywords:

Bioink Biomaterials Coaxial 3D bioprinting Controlled delivery Focused ultrasound Gene delivery Microbubbles Sonoporation Ultrasound

More Related Videos

Automated Robotic Dispensing Technique for Surface Guidance and Bioprinting of Cells

Automated Robotic Dispensing Technique for Surface Guidance and Bioprinting of Cells

Published on: November 18, 2016

Bioprinting of Cartilage and Skin Tissue Analogs Utilizing a Novel Passive Mixing Unit Technique for Bioink Precellularization

Bioprinting of Cartilage and Skin Tissue Analogs Utilizing a Novel Passive Mixing Unit Technique for Bioink Precellularization

Published on: January 3, 2018

Related Experiment Videos

Last Updated: Jun 28, 2026

Bioprinting Cellularized Constructs Using a Tissue-specific Hydrogel Bioink

Bioprinting Cellularized Constructs Using a Tissue-specific Hydrogel Bioink

Published on: April 21, 2016

Automated Robotic Dispensing Technique for Surface Guidance and Bioprinting of Cells

Automated Robotic Dispensing Technique for Surface Guidance and Bioprinting of Cells

Published on: November 18, 2016

Bioprinting of Cartilage and Skin Tissue Analogs Utilizing a Novel Passive Mixing Unit Technique for Bioink Precellularization

Bioprinting of Cartilage and Skin Tissue Analogs Utilizing a Novel Passive Mixing Unit Technique for Bioink Precellularization

Published on: January 3, 2018

Area of Science:

Biotechnology
Regenerative Medicine
Biomaterials

Background:

Coaxial 3D bioprinting creates advanced tissue constructs for disease modeling and therapies.
Controlling gene expression in 3D scaffolds is challenging due to limited vector diffusion.
Existing transfection methods lack spatiotemporal control in dense 3D bioprinted structures.

Purpose of the Study:

To develop a 3D bioprinting technique with controlled gene delivery capabilities.
To overcome limitations of traditional transfection methods in dense 3D scaffolds.
To enable spatiotemporally-defined genetic manipulation in engineered tissues.

Main Methods:

Developed coaxial extrusion 3D bioprinting using ultrasound-responsive gene delivery bioinks.
Incorporated phospholipid-coated microbubbles with DNA payloads into cell-laden alginate bioinks.
Utilized focused ultrasound to induce sonoporation and facilitate DNA delivery into cells within bioprinted constructs.

Main Results:

Established coaxial printing parameters maintaining particle stability and high cell viability for 48 hours.
Achieved successful sonoporation, DNA delivery, and ultrasound-controlled transgene expression.
Demonstrated modulation of transfected cell number and delivery region by adjusting ultrasound pulses and microbubble concentration.

Conclusions:

Presented a successful coaxial 3D bioprinting technique for ultrasound-controlled gene delivery.
This platform allows remote, spatiotemporally-defined genetic manipulation in bioprinted tissue constructs.
The technique has significant applications in disease modeling and regenerative medicine.