[Neutron activation analysis in modelling the elimination from the kidneys of cis-dichlorodiammineplatinum]

A neutron activation analysis was used for a study of platinum elimination from the kidneys of male rats after administration of cis-DDP at a dose of 7 mg per 1 kg of the animal body mass. The literature data on beagles were taken for comparison. A simple mathematical model for platinum elimination from the kidneys was proposed: the platinum content was 2.27 micrograms per 1 g of raw tissue for the time interval of 3h less than or equal to t less than or equal to 1 day; 2.34 X X t(-0,51) micrograms/g for t greater than 1 day and a dose of 1 mg per 1 kg of the animal body mass. An opportunity to predict the platinum content in the human kidneys was tested.