Related Experiment Video

Updated: Jun 8, 2025

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
07:23

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Published on: May 30, 2025

147

CRISPR-mediated silencing of non-coding RNAs: A novel putative treatment for prostate cancer

Mobina Tabibian1, Soudeh Ghafouri-Fard1

  • 1Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Pathology, Research and Practice
|November 8, 2024
PubMed

Insights

Non-coding RNAs drive prostate cancer. CRISPR/Cas9 technology offers new ways to control these oncogenes, potentially improving treatments for invasion and metastasis.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Non-coding RNAs play a role in prostate cancer development.
  • Some non-coding RNAs function as oncogenes, promoting cancer growth.
  • These oncogenes are potential therapeutic targets for prostate cancer.

Purpose of the Study:

  • To review recent advancements in modulating non-coding RNA expression.
  • To explore the application of CRISPR/Cas9 technology in prostate cancer research.
  • To highlight the potential of CRISPR/Cas9 for targeting oncogenic non-coding RNAs.

Main Methods:

  • Literature review of studies using CRISPR/Cas9 for non-coding RNA modulation.
  • Focus on applications in prostate cancer models.
  • Analysis of CRISPR/Cas9's efficacy in targeting oncogenes.

Main Results:

  • CRISPR/Cas9 enables precise control over non-coding RNA expression.
  • This technology can impact prostate cancer hallmarks like invasion and metastasis.
  • Novel strategies for targeting oncogenic non-coding RNAs are emerging.

Conclusions:

  • CRISPR/Cas9 technology is a promising tool for modulating non-coding RNAs in prostate cancer.
  • Targeting oncogenic non-coding RNAs with CRISPR/Cas9 may offer new therapeutic avenues.
  • Further research is needed to translate these findings into clinical applications.
Keywords:
CRISPR/Cas9Non-coding RNAProstate cancer

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