Related Experiment Video
Updated: Jul 12, 2026

Drug-induced Sensitization of Adenylyl Cyclase: Assay Streamlining and Miniaturization for Small Molecule and siRNA Screening Applications
Published on: January 27, 2014
Senescence does not alter activation or inhibition of striatal adenylate cyclase
Abstract:
The effects of senescence on the striatal adenylate cyclase system were investigated in 8-10 and 28-30 month old male, CDF(F-344) rats. No difference was observed between the two groups of animals in the activation of adenylate cyclase by dopamine, manganese chloride or sodium fluoride. Similarly, the potency and efficacy of morphine and acetylcholine to inhibit adenylate cyclase activity were not different in the two groups of rats. Thus, the components of the adenylate cyclase system, as well as the coupling of this system to the dopamine, opiate and muscarinic receptors are not changed during senescence.
Related Concept Videos
GPCR Desensitization
GPCRs Regulate Adenylyl Cylase Activity
Two...
Indirect-Acting Cholinergic Agonists: Mechanism of Action
Reversible inhibitors like edrophonium bind to a specific part of the enzyme called the anionic catalytic site. They form noncovalent bonds, which means they are not strongly attached to the enzyme. This creates a temporary and less stable enzyme–inhibitor complex, leading to...
Adrenergic Agonists: Indirect-Acting Agents
One mechanism involves depleting stored catecholamines by displacing them from synaptic vesicles. These agents, known as "displacers," are transported into vesicles at the expense of noradrenaline. Examples include amphetamine and tyramine, which lack a catechol moiety, resulting in prolonged action, improved oral bioavailability, and...
Drugs Affecting Neurotransmitter Release or Uptake
Drugs Affecting Neurotransmitter Synthesis

